The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells
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چکیده
The altered metabolism of cancer cells was recognized and pioneered by the elegant works of Otto Warburg in the 1920s and popularized in the 1950s. Presently, it is well recognized that over sixty percent of all cancers are glycolytic. The Warburg effect or phenomenon is discussed, and the molecular understanding of some of Warburg’s statements is provided with regard to modern knowledge of carcinogenesis. In addition, molecular explanation of aerobic glycolysis of the cancer cell is detailed. Other metabolic alterations of the cancer cell including glutaminolysis and lipogenesis are discussed. The altered citrate metabolism specifically associated with malignant transformation of peripheral zone prostate epithelial cells, and the potential clinical applications of such metabolic alterations conclude this chapter.
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The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells
The altered metabolism of cancer cells was recognized and pioneered by the elegant works of Otto Warburg in the 1920s and popularized in the 1950s. Presently, it is well recognized that over sixty percent of all cancers are glycolytic. The Warburg effect or phenomenon is discussed, and the molecular understanding of some of Warburg’s statements is provided with regard to modern knowledge of car...
متن کاملThe Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells
The altered metabolism of cancer cells was recognized and pioneered by the elegant works of Otto Warburg in the 1920s and popularized in the 1950s. Presently, it is well recognized that over sixty percent of all cancers are glycolytic. The Warburg effect or phenomenon is discussed, and the molecular understanding of some of Warburg’s statements is provided with regard to modern knowledge of car...
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